CRISPR/Cas9 Genome-Editing System in Human Stem Cells: Current Status and Future Prospects

• Main Authors: Zhao Zhang (Author), Yuelin Zhang (Author), Fei Gao (Author), Shuo Han (Author), Kathryn S. Cheah (Author), Hung-Fat Tse (Author), Qizhou Lian (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genome-editing involves the insertion, deletion, or replacement of DNA in the genome of a living organism using "molecular scissors." Traditional genome editing with engineered nucleases for human stem cells is limited by its low efficiency, high cost, and poor specificity. The CRISPR syst...