Optimization of the Linker Length of Mannose-Cholesterol Conjugates for Enhanced mRNA Delivery to Dendritic Cells by Liposomes

• Main Authors: Fazhan Wang (Author), Wen Xiao (Author), Mostafa A. Elbahnasawy (Author), Xingting Bao (Author), Qian Zheng (Author), Linhui Gong (Author), Yang Zhou (Author), Shuping Yang (Author), Aiping Fang (Author), Mohamed M. S. Farag (Author), Jinhui Wu (Author), Xiangrong Song (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liposomes (LPs) as commonly used mRNA delivery systems remain to be rationally designed and optimized to ameliorate the antigen expression of mRNA vaccine in dendritic cells (DCs). In this study, we synthesized mannose-cholesterol conjugates (MPn-CHs) by click reaction using different PEG units (PEG...