Propionic Acid Targets the TLR4/NF-κB Signaling Pathway and Inhibits LPS-Induced Intestinal Barrier Dysfunction: In Vitro and In Vivo Studies

• Main Authors: Randong Yang (Author), Xiaoxiao Hu (Author), Xianzheng Xie (Author), Haiqiong Chen (Author), Huangyi Fang (Author), Libing Zhu (Author), Zhongrong Li (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Fag: article
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Intestinal barrier dysfunction contributes to the development of intestinal diseases. Propionic acid (PA), a metabolite generated by anaerobic fermentation of dietary fiber in the intestinal cavity, has been proved to exert anti-inflammatory effects in a variety of diseases. However, the exact role...