The establishment of surrogates and correlates of protection: Useful tools for the licensure of effective influenza vaccines?

• Main Authors: Brian J. Ward (Author), Stephane Pillet (Author), Nathalie Charland (Author), Sonia Trepanier (Author), Julie Couillard (Author), Nathalie Landry (Author)
• 格式: 图书
• 出版: Taylor & Francis Group, 2018-03-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

The search for a test that can predict vaccine efficacy is an important part of any vaccine development program. Although regulators hesitate to acknowledge any test as a true 'correlate of protection', there are many precedents for defining 'surrogate' assays. Surrogates can be...