Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress

• Main Authors: Nevertyty Mohamed Mahmoud (Author), Shimaa M. Elshazly (Author), Fatma El-shaarawy (Author), Sawsan A. Zaitone (Author), Afaf A. Aldahish (Author), Gehan A. Ahmed (Author), Manal S. Fawzy (Author), Sheka Yagub Aloyouni (Author), Sally Y. Abed (Author), Tahani Saeedi (Author), Shaimaa S. El-Sayed (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ObjectivesHepatotoxicity is a severe outcome of methotrexate (MTX) therapy, limiting its clinical use and contributing to its related morbidity and mortality. This study investigated the hepatoprotective effects of nitazoxanide (NTZ), an antiprotozoal drug, against MTX-induced hepatotoxicity and whe...