Identification of a Potent Allosteric Inhibitor of Human Protein Kinase CK2 by Bacterial Surface Display Library Screening

Human protein kinase CK2 has emerged as promising target for the treatment of neoplastic diseases. The vast majority of kinase inhibitors known today target the ATP binding site, which is highly conserved among kinases and hence leads to limited selectivity. In order to identify non-ATP competitive...

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Main Authors: Christian Nienberg (Author), Claudia Garmann (Author), Andreas Gratz (Author), Andre Bollacke (Author), Claudia Götz (Author), Joachim Jose (Author)
Format: Knjiga
Izdano: MDPI AG, 2017-01-01T00:00:00Z.
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