Nicousamide, a potent inhibitor of phosphorylation by TGF-β receptor II

• Main Authors: Hai-jing Zhang (Author), Jing Jin (Author), Wan-qi Zhou (Author), Yi Zhang (Author), Yan Li (Author), Jian-yi Liu (Author), Sen Zhang (Author), Xiao-guang Chen (Author)
• Format: Book
• Published: Elsevier, 2011-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Renal fibrogenesis is related to the development of diabetic nephropathy. TGF-β receptor II (TGF-β RII) plays a vital role during renal fibrogenesis by phosphorylation and activation of type I receptors and downstream regulators. Nicousamide is a 1.1 class of drug, which can inhibit renal fibrosis i...