Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.

• Main Authors: Marc P Hübner (Author), Alexandra Ehrens (Author), Marianne Koschel (Author), Bettina Dubben (Author), Franziska Lenz (Author), Stefan J Frohberger (Author), Sabine Specht (Author), Ludo Quirynen (Author), Sophie Lachau-Durand (Author), Fetene Tekle (Author), Benny Baeten (Author), Marc Engelen (Author), Charles D Mackenzie (Author), Achim Hoerauf (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Flubendazole (FBZ) is highly efficacious against filarial nematodes after parenteral administration and presents a promising macrofilaricidal drug candidate for the elimination of onchocerciasis and other filariae. In the present study the efficacy of a newly developed bioavailable amorphous solid d...