Bladder Endothelin-1 Receptor Binding of Bosentan and Ambrisentan

• Main Authors: Ayaka Osano (Author), Yoshinari Yokoyama (Author), Hideki Hayashi (Author), Kunihiko Itoh (Author), Takashi Okura (Author), Yoshiharu Deguchi (Author), Yoshihiko Ito (Author), Shizuo Yamada (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: The present study aimed to characterize bladder endothelin-1 (ET-1) receptor binding of clinically used ET-1 receptor antagonists by using [125I]ET-1. The inhibition of specific [125I]ET-1 binding was measured in the presence of ET-1 and its receptor antagonists. Specific binding of [125I...