PIK3CA mutation correlates with mTOR pathway expression but not clinical and pathological features in Fibfibroipose vascular anomaly (FAVA)

• Main Authors: Yumiko Hori (Author), Katsutoshi Hirose (Author), Michio Ozeki (Author), Kenji Hata (Author), Daisuke Motooka (Author), Shinichiro Tahara (Author), Takahiro Matsui (Author), Masaharu Kohara (Author), Hiroki Higashihara (Author), Yusuke Ono (Author), Kaishu Tanaka (Author), Satoru Toyosawa (Author), Eiichi Morii (Author)
• Format: Book
• Published: BMC, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Fibro-adipose vascular anomaly (FAVA) is a rare and new entity of vascular anomaly. Activating mutations in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene were identified at a frequency of 62.5% in FAVA cases. The PIK3CA mutations excessi...