Blockade of cholinergic transmission elicits somatic signs in nicotine-naïve adolescent rats
High doses of the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine can elicit somatic signs resembling those associated with nicotine withdrawal in nicotine-naïve adult rats. Understanding this phenomenon, and its possible modulation by acute nicotine and age, could inform the use of...
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Frontiers Media S.A.,
2015-10-01T00:00:00Z.
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