Aminoglycoside 6'-<i>N</i>-acetyltransferase Type Ib [AAC(6')-Ib]-Mediated Aminoglycoside Resistance: Phenotypic Conversion to Susceptibility by Silver Ions

• Main Authors: Craig M. Reeves (Author), Jesus Magallon (Author), Kenneth Rocha (Author), Tung Tran (Author), Kimberly Phan (Author), Peter Vu (Author), Yang Yi (Author), Crista L. Oakley-Havens (Author), José Cedano (Author), Verónica Jimenez (Author), Maria S. Ramirez (Author), Marcelo E. Tolmasky (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clinical resistance to amikacin and other aminoglycosides is usually due to the enzymatic acetylation of the antimicrobial molecule. A ubiquitous resistance enzyme among Gram-negatives is the aminoglycoside 6'-<i>N</i>-acetyltransferase type Ib [AAC(6')-Ib], which catalyzes ace...