Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients

• Main Authors: Jialian Zhao (Author), Qiang Gu (Author), Lifeng Wang (Author), Weize Xu (Author), Lihua Chu (Author), Ya Wang (Author), Zhongwang Li (Author), Shuijing Wu (Author), Jianguo Xu (Author), Zhiyong Hu (Author), Qiang Shu (Author), Xiangming Fang (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DEFA1/DEFA3, genes encoding human neutrophil peptides (HNP) 1-3, display wide-ranging copy number variations (CNVs) and is functionally associated with innate immunity and infections. To identify potential associations between DEFA1/DEFA3 CNV and hospital-acquired infections (HAIs), we enrolled 106...