Acute pharmacodynamic responses to sitagliptin: Drug‐induced increase in early insulin secretion in oral glucose tolerance test

• Main Authors: Amber L. Beitelshees (Author), Elizabeth A. Streeten (Author), Zhinous Shahidzadeh Yazdi (Author), Hilary B. Whitlatch (Author), Braxton D. Mitchell (Author), Alan R. Shuldiner (Author), May E. Montasser (Author), Simeon I. Taylor (Author)
• Format: Book
• Published: Wiley, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract DPP4 inhibitors are widely prescribed as treatments for type 2 diabetes. Because drug responses vary among individuals, we initiated investigations to identify genetic variants associated with the magnitude of drug responses. Sitagliptin (100 mg) was administered to 47 healthy volunteers. S...