Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy

• Prif Awduron: Marzia Cirri (Awdur), Lavinia Maestrini (Awdur), Francesca Maestrelli (Awdur), Natascia Mennini (Awdur), Paola Mura (Awdur), Carla Ghelardini (Awdur), Lorenzo Di Cesare Mannelli (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The hydrochlorothiazide (HCT) low solubility and permeability give rise to limited and variable bioavailability; its low stability makes it difficult to develop stable aqueous liquid formulations; its low dose makes the achievement of a homogeneous drug distribution very difficult. Thus, the aim of...