Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy

• Main Authors: Marzia Cirri (Author), Lavinia Maestrini (Author), Francesca Maestrelli (Author), Natascia Mennini (Author), Paola Mura (Author), Carla Ghelardini (Author), Lorenzo Di Cesare Mannelli (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The hydrochlorothiazide (HCT) low solubility and permeability give rise to limited and variable bioavailability; its low stability makes it difficult to develop stable aqueous liquid formulations; its low dose makes the achievement of a homogeneous drug distribution very difficult. Thus, the aim of...