Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521

• Main Authors: Masayuki Nakano (Author), Kinnosuke Yahiro (Author), Eiki Yamasaki (Author), Hisao Kurazono (Author), Junko Akada (Author), Yoshio Yamaoka (Author), Takuro Niidome (Author), Masanori Hatakeyama (Author), Hidekazu Suzuki (Author), Taro Yamamoto (Author), Joel Moss (Author), Hajime Isomoto (Author), Toshiya Hirayama (Author)
• Format: Book
• Published: The Company of Biologists, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Helicobacter pylori, a major cause of gastroduodenal diseases, produces vacuolating cytotoxin (VacA) and cytotoxin-associated gene A (CagA), which seem to be involved in virulence. VacA exhibits pleiotropic actions in gastroduodenal disorders via its specific receptors. Recently, we found that VacA...