High-Fat Diet-Induced Obesity Increases Brain Mitochondrial Complex I and Lipoxidation-Derived Protein Damage

• Main Authors: Rebeca Berdún (Author), Èlia Obis (Author), Natàlia Mota-Martorell (Author), Anna Bassols (Author), Daniel Valent (Author), José C. E. Serrano (Author), Meritxell Martín-Garí (Author), María Rodríguez-Palmero (Author), José Antonio Moreno-Muñoz (Author), Joan Tibau (Author), Raquel Quintanilla (Author), Reinald Pamplona (Author), Manuel Portero-Otín (Author), Mariona Jové (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Obesity is a risk factor for highly prevalent age-related neurodegenerative diseases, the pathogenesis of whichinvolves mitochondrial dysfunction and protein oxidative damage. Lipoxidation, driven by high levels of peroxidizable unsaturated fatty acids and low antioxidant protection of the brain, st...