Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer

• Main Authors: Hanne-Line Rabben (Author), Gøran Troseth Andersen (Author), Aleksandr Ianevski (Author), Magnus Kringstad Olsen (Author), Denis Kainov (Author), Jon Erik Grønbech (Author), Timothy Cragin Wang (Author), Duan Chen (Author), Chun-Mei Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The aim of the present study was repositioning of ivermectin in treatment of gastric cancer (GC) by computational prediction based on gene expression profiles of human and mouse model of GC and validations with in silico, in vitro and in vivo approaches.Methods: Computational drug reposit...