Preclinical evaluation of the ROCK1 inhibitor, GSK269962A, in acute myeloid leukemia

• Główni autorzy: Ting Pan (Autor), Sijia Wang (Autor), Hao Feng (Autor), Jiawen Xu (Autor), Miao Zhang (Autor), Yao Yao (Autor), Kailin Xu (Autor), Mingshan Niu (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with high mortality that urgently requires new treatments. ROCK1 plays an essential role in regulating growth and survival in AML cells. In this study, we evaluated GSK269962A, a selective ROCK1 inhibitor, in preclinical models of...