Preclinical evaluation of the ROCK1 inhibitor, GSK269962A, in acute myeloid leukemia

• Main Authors: Ting Pan (Author), Sijia Wang (Author), Hao Feng (Author), Jiawen Xu (Author), Miao Zhang (Author), Yao Yao (Author), Kailin Xu (Author), Mingshan Niu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with high mortality that urgently requires new treatments. ROCK1 plays an essential role in regulating growth and survival in AML cells. In this study, we evaluated GSK269962A, a selective ROCK1 inhibitor, in preclinical models of...