Evaluation of Potential Herb-Drug Interactions Between Shengmai Injection and Losartan Potassium in Rat and In Vitro

• Главные авторы: Zhenchao Niu (Автор), Tingting Qiang (Автор), Wenyong Lin (Автор), Yiping Li (Автор), Keyan Wang (Автор), Dan Wang (Автор), Xiaolong Wang (Автор)
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• Опубликовано: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Предметы: article
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Aim: The present study aimed to explore the potential herb-drug interactions (HDI) between Shengmai injection (SMI) and losartan potassium (LOS) based on the expression profiles of cytochromes P450 (CYP450) and drug transporters in rat and in vitro.Methods: Different concentrations of SMI were used...