Process Design of Continuous Powder Blending Using Residence Time Distribution and Feeding Models

• Egile Nagusiak: Martin Gyürkés (Egilea), Lajos Madarász (Egilea), Ákos Köte (Egilea), András Domokos (Egilea), Dániel Mészáros (Egilea), Áron Kristóf Beke (Egilea), Brigitta Nagy (Egilea), György Marosi (Egilea), Hajnalka Pataki (Egilea), Zsombor Kristóf Nagy (Egilea), Attila Farkas (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2020-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The present paper reports a thorough continuous powder blending process design of acetylsalicylic acid (ASA) and microcrystalline cellulose (MCC) based on the Process Analytical Technology (PAT) guideline. A NIR-based method was applied using multivariate data analysis to achieve in-line process mon...