Comprehensive alpha, beta, and delta cell transcriptomics reveal an association of cellular aging with MHC class I upregulation

• Ngā kaituhi matua: W. Staels (Author), C. Berthault (Author), S. Bourgeois (Author), V. Laville (Author), C. Lourenço (Author), N. De Leu (Author), R. Scharfmann (Author)
• Hōputu: Pukapuka
• I whakaputaina: Elsevier, 2024-09-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Objectives: This study aimed to evaluate the efficacy of a purification method developed for isolating alpha, beta, and delta cells from pancreatic islets of adult mice, extending its application to islets from newborn and aged mice. Furthermore, it sought to examine transcriptome dynamics in mouse...