A Systematic Screening of Traditional Chinese Medicine Identifies Two Novel Inhibitors Against the Cytotoxic Aggregation of Amyloid Beta

• Main Authors: Liang Ma (Author), Jiaojiao Zheng (Author), Huijing Chen (Author), Xia Zeng (Author), Shilin Wang (Author), Chen Yang (Author), Xi Li (Author), Yushuo Xiao (Author), Ling Zheng (Author), Hong Chen (Author), Kun Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The toxic aggregates of amyloid beta (Aβ) disrupt the cell membrane, induce oxidative stress and mitochondrial dysfunction, and eventually lead to Alzheimer's disease (AD). Intervening with this cytotoxic aggregation process has been suggested as a potential therapeutic approach for AD and othe...