Physicochemical properties determining drug detection in skin

• Main Authors: Wout Bittremieux (Author), Rohit S. Advani (Author), Alan K. Jarmusch (Author), Shaden Aguirre (Author), Aileen Lu (Author), Pieter C. Dorrestein (Author), Shirley M. Tsunoda (Author)
• Format: Book
• Published: Wiley, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Chemicals, including some systemically administered xenobiotics and their biotransformations, can be detected noninvasively using skin swabs and untargeted metabolomics analysis. We sought to understand the principal drivers that determine whether a drug taken orally or systemically is like...