N-n-Butyl Haloperidol Iodide, a Derivative of the Anti-psychotic Haloperidol, Antagonizes Hypoxia/Reoxygenation Injury by Inhibiting an Egr-1/ROS Positive Feedback Loop in H9c2 Cells

• Main Authors: Ting Sun (Author), Yanmei Zhang (Author), Shuping Zhong (Author), Fenfei Gao (Author), Yicun Chen (Author), Bin Wang (Author), Wenfeng Cai (Author), Zhaojing Zhang (Author), Weiqiu Li (Author), Shishi Lu (Author), Fuchun Zheng (Author), Ganggang Shi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Early growth response-1 (Egr-1), a transcription factor which often underlies the molecular basis of myocardial ischemia/reperfusion (I/R) injury, and oxidative stress, is key to myocardial I/R injury. Silent information regulator of transcription 1(SIRT1) not only interacts with and is inhibited by...