Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits

• मुख्य लेखकों: Hasan Çağın Lenk (लेखक), Robert Løvsletten Smith (लेखक), Kevin S. O'Connell (लेखक), Marin M. Jukić (लेखक), Marianne Kristiansen Kringen (लेखक), Ole A. Andreassen (लेखक), Magnus Ingelman‐Sundberg (लेखक), Espen Molden (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2023-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Clinical response of clozapine is closely associated with serum concentration. Although tobacco smoking is the key environmental factor underlying interindividual variability in clozapine metabolism, recent genome‐wide studies suggest that CYP1A and NFIB genetic variants may also be of sign...