Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits

• Asıl Yazarlar: Hasan Çağın Lenk (Yazar), Robert Løvsletten Smith (Yazar), Kevin S. O'Connell (Yazar), Marin M. Jukić (Yazar), Marianne Kristiansen Kringen (Yazar), Ole A. Andreassen (Yazar), Magnus Ingelman‐Sundberg (Yazar), Espen Molden (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2023-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Clinical response of clozapine is closely associated with serum concentration. Although tobacco smoking is the key environmental factor underlying interindividual variability in clozapine metabolism, recent genome‐wide studies suggest that CYP1A and NFIB genetic variants may also be of sign...