Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits

• Main Authors: Hasan Çağın Lenk (Author), Robert Løvsletten Smith (Author), Kevin S. O'Connell (Author), Marin M. Jukić (Author), Marianne Kristiansen Kringen (Author), Ole A. Andreassen (Author), Magnus Ingelman‐Sundberg (Author), Espen Molden (Author)
• Format: Book
• Published: Wiley, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Clinical response of clozapine is closely associated with serum concentration. Although tobacco smoking is the key environmental factor underlying interindividual variability in clozapine metabolism, recent genome‐wide studies suggest that CYP1A and NFIB genetic variants may also be of sign...