Oral and intravenous pharmacokinetics of metformin with and without oral codeine intake in healthy subjects: A cross‐over study

• Main Authors: Ida Kuhlmann (Author), Amanda Nøddebo Nyrup (Author), Tore Bjerregaard Stage (Author), Mette Marie Hougaard Christensen (Author), Troels Korshøj Bergmann (Author), Per Damkier (Author), Flemming Nielsen (Author), Kurt Højlund (Author), Kim Brøsen (Author)
• Format: Book
• Published: Wiley, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The aim of the study was to investigate if there is a clinically relevant drug interaction between metformin and codeine. Volunteers were randomized to receive on four separate occasions: (A) orally administered metformin (1 g), (B) intravenously administered metformin (0.5 g), (C) five dos...