Diazepam is not a direct allosteric modulator of α1‐adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase‐4

• Main Authors: Lisa M. Williams (Author), Xiaoji He (Author), Tasneem M. Vaid (Author), Alaa Abdul‐Ridha (Author), Alice R. Whitehead (Author), Paul R. Gooley (Author), Ross A.D. Bathgate (Author), Spencer J. Williams (Author), Daniel J. Scott (Author)
• Format: Book
• Published: Wiley, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract α1A‐ and α1B‐adrenoceptors (ARs) are G protein‐coupled receptors (GPCRs) that are activated by adrenaline and noradrenaline to modulate smooth muscle contraction in the periphery, and neuronal outputs in the central nervous system (CNS). α1A‐ and α1B‐AR are clinically targeted with antagoni...