Demethylating Agents in the Treatment of Cancer
Gene silencing resulting from aberrant DNA methylation can lead to tumorigenesis. Therefore, drugs that inhibit or interfere with DNA methylation have been used to reactivate and induce silenced gene re-expression in malignancies. Two demethylating agents, azacitidine and decitabine, are approved fo...
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MDPI AG,
2010-07-01T00:00:00Z.
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