Optimized functional and structural design of dual-target LMRAP, a bifunctional fusion protein with a 25-amino-acid antitumor peptide and GnRH Fc fragment

• Main Authors: Meng Li (Author), Hanmei Xu (Author), Junzhi Wang (Author)
• 格式: 圖書
• 出版: Elsevier, 2020-02-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

To develop fusion protein of a GnRH Fc fragment and the integrin targeting AP25 antitumor peptide for GnRH receptor-expressing cancer therapy. The LMRAP fusion protein was constructed. A transwell invasion assay was performed. The gene mRNA and protein levels of GnRHR-I, α5β1, and αvβ3 in different...