SAR Study and Molecular Mechanism Investigation of Novel Naphthoquinone-furan-2-cyanoacryloyl Hybrids with Antitumor Activity

• Главные авторы: Pingxian Liu (Автор), Dongmei Fan (Автор), Wenliang Qiao (Автор), Xinlian He (Автор), Lidan Zhang (Автор), Yunhan Jiang (Автор), Tao Yang (Автор)
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• Опубликовано: MDPI AG, 2022-10-01T00:00:00Z.
• Предметы: article
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A series of novel naphthoquinone-furan-2-cyanoacryloyl hybrids were designed; they were synthesized and preliminarily evaluated for their anti-proliferative activities in vitro against several cancer cell lines and normal cells. The most potent compound, <b>5c</b>, inhibited the prolifer...