Novel piperazine‐based ionizable lipid nanoparticles allow the repeated dose of mRNA to fibrotic lungs with improved potency and safety

• Main Authors: Minjeong Kim (Author), Michaela Jeong (Author), Gyeongseok Lee (Author), Yeji Lee (Author), Jeongeun Park (Author), Hyein Jung (Author), Seongeun Im (Author), Joo‐Sung Yang (Author), Kyungjin Kim (Author), Hyukjin Lee (Author)
• Format: Book
• Published: Wiley, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract mRNA‐based protein replacement therapy has received much attention as a novel intervention in clinical disease treatment. Lipid nanoparticles (LNPs) are widely used for their therapeutic potential to efficiently deliver mRNA. However, clinical translation has been hampered by the immunogeni...