Preparation of Hot-Melt-Extruded Solid Dispersion Based on Pre-Formulation Strategies and Its Enhanced Therapeutic Efficacy

• Main Authors: Seon-Kwang Lee (Author), Eun-Sol Ha (Author), Heejun Park (Author), Kyu-Tae Kang (Author), Ji-Su Jeong (Author), Jeong-Soo Kim (Author), In-hwan Baek (Author), Min-Soo Kim (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, an amorphous solid dispersion containing the poorly water-soluble drug, bisacodyl, was prepared by hot-melt extrusion to enhance its therapeutic efficacy. First, the miscibility and interaction between the drug and polymer were investigated as pre-formulation strategies using various...