Co-Delivery of M2e Virus-Like Particles with Influenza Split Vaccine to the Skin Using Microneedles Enhances the Efficacy of Cross Protection

• Prif Awduron: Min-Chul Kim (Awdur), Ki-Hye Kim (Awdur), Jeong Woo Lee (Awdur), Yu-Na Lee (Awdur), Hyo-Jick Choi (Awdur), Yu-Jin Jung (Awdur), Yu-Jin Kim (Awdur), Richard W. Compans (Awdur), Mark R. Prausnitz (Awdur), Sang-Moo Kang (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2019-04-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

It is a high priority to develop a simple and effective delivery method for a cross-protective influenza vaccine. We investigated skin immunization by microneedle (MN) patch with human influenza split vaccine and virus-like particles containing heterologous M2 extracellular (M2e) domains (M2e5x viru...