Co-Delivery of M2e Virus-Like Particles with Influenza Split Vaccine to the Skin Using Microneedles Enhances the Efficacy of Cross Protection

• Main Authors: Min-Chul Kim (Author), Ki-Hye Kim (Author), Jeong Woo Lee (Author), Yu-Na Lee (Author), Hyo-Jick Choi (Author), Yu-Jin Jung (Author), Yu-Jin Kim (Author), Richard W. Compans (Author), Mark R. Prausnitz (Author), Sang-Moo Kang (Author)
• Format: Book
• Published: MDPI AG, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It is a high priority to develop a simple and effective delivery method for a cross-protective influenza vaccine. We investigated skin immunization by microneedle (MN) patch with human influenza split vaccine and virus-like particles containing heterologous M2 extracellular (M2e) domains (M2e5x viru...