Inhibition of Heme Oxygenase Antioxidant Activity Exacerbates Hepatic Steatosis and Fibrosis <i>In Vitro</i>

• Main Authors: Marco Raffaele (Author), Giuseppe Carota (Author), Giuseppe Sferrazzo (Author), Maria Licari (Author), Ignazio Barbagallo (Author), Valeria Sorrenti (Author), Salvatore S. Signorelli (Author), Luca Vanella (Author)
• Format: Book
• Published: MDPI AG, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The progression of non-alcoholic fatty liver disease (NAFLD) and the development of hepatic fibrosis is caused by changes in redox balance, leading to an increase of reactive oxygen species (ROS) levels. NAFLD patients are at risk of progressing to non-alcoholic steatohepatitis (NASH), associated to...