Preformulation Studies of Ezetimibe-Simvastatin Solid Dispersions in the Development of Fixed-Dose Combinations

Two active pharmaceutical ingredients (APIs) with limited solubility, simvastatin and ezetimibe, prepared as a drug-drug solid dispersion (SD) was evaluated for physicochemical, microstructural, and aqueous dissolution properties. The simvastatin-ezetimibe SD was prepared using the co-grinding metho...

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Main Authors: Agata Górniak (Author), Adrianna Złocińska (Author), Mateusz Trojan (Author), Adrianna Pęcak (Author), Bożena Karolewicz (Author)
Format: Book
Published: MDPI AG, 2022-04-01T00:00:00Z.
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