Long-term maintenance of dystrophin expression and resistance to injury of skeletal muscle in gene edited DMD mice

Long-term maintenance of dystrophin expression and resistance to injury of skeletal muscle in gene edited DMD mice

Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by mutations in the dystrophin gene. CRISPR/Cas9 genome editing has been used to correct DMD mutations in animal models at young ages. However, the longevity and durability of CRISPR/Cas9 editing remained to be determined. To addres...

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Main Authors: Dileep R. Karri (Author), Yu Zhang (Author), Francesco Chemello (Author), Yi-Li Min (Author), Jian Huang (Author), Jiwoong Kim (Author), Pradeep P.A. Mammen (Author), Lin Xu (Author), Ning Liu (Author), Rhonda Bassel-Duby (Author), Eric N. Olson (Author)
Format: Book
Published: Elsevier, 2022-06-01T00:00:00Z.
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