Long-term maintenance of dystrophin expression and resistance to injury of skeletal muscle in gene edited DMD mice

• প্রধান লেখক: Dileep R. Karri (লেখক), Yu Zhang (লেখক), Francesco Chemello (লেখক), Yi-Li Min (লেখক), Jian Huang (লেখক), Jiwoong Kim (লেখক), Pradeep P.A. Mammen (লেখক), Lin Xu (লেখক), Ning Liu (লেখক), Rhonda Bassel-Duby (লেখক), Eric N. Olson (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2022-06-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by mutations in the dystrophin gene. CRISPR/Cas9 genome editing has been used to correct DMD mutations in animal models at young ages. However, the longevity and durability of CRISPR/Cas9 editing remained to be determined. To addres...