Formation of Tumorspheres with Increased Stemness without External Mitogens in a Lung Cancer Model

• Main Authors: Juan Sebastian Yakisich (Author), Neelam Azad (Author), Rajkumar Venkatadri (Author), Yogesh Kulkarni (Author), Clayton Wright (Author), Vivek Kaushik (Author), Anand Krishnan V. Iyer (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Like with most solid tumors, the presence of a subpopulation of cancer stem cells (CSCs) or cancer stem-like cells (CS-LCs) has been associated with chemoresistance and tumor relapse in lung cancer cells. In the absence of serum, CSCs/CS-LCs have the ability to grow as lung tumorspheres (LTSs), and...