Frequent low-impact exposure to THC during adolescence causes persistent sexually dimorphic alterations in the response to viral infection in mice

• Main Authors: Hye-Lim Lee (Author), Erica Squire (Author), Yannick Fotio (Author), Alex Mabou Tagne (Author), Jungyeon Lee (Author), John Jeongwoo Yoon (Author), Yedam Hong (Author), Laura Hyunseo Kim (Author), Kwang-Mook Jung (Author), Daniele Piomelli (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adolescent exposure to Δ9-tetrahydrocannabinol (THC) has enduring effects on energy metabolism and immune function. Prior work showed that daily administration of a low-impact dose of THC (5 mg/kg, intraperitoneal) during adolescence alters transcription in adult microglia and disrupts their respons...