Glycolytic inhibitor 2-deoxyglucose simultaneously targets cancer and endothelial cells to suppress neuroblastoma growth in mice

• Main Authors: Chao-Cheng Huang (Author), Shuo-Yu Wang (Author), Li-Ling Lin (Author), Pei-Wen Wang (Author), Ting-Ya Chen (Author), Wen-Ming Hsu (Author), Tsu-Kung Lin (Author), Chia-Wei Liou (Author), Jiin-Haur Chuang (Author)
• Format: Book
• Published: The Company of Biologists, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuroblastoma is characterized by a wide range of clinical manifestations and associated with poor prognosis when there is amplification of MYCN oncogene or high expression of Myc oncoproteins. In a previous in vitro study, we found that the glycolytic inhibitor 2-deoxyglucose (2DG) could suppress t...