Establishment of a pharmacokinetics and pharmacodynamics model of Schisandra lignans against hippocampal neurotransmitters in AD rats based on microdi-alysis liquid chromatography-mass spectrometry

• Main Authors: Jinpeng Zhang (Author), Xinyuan Cui (Author), Shuo Zhao (Author), Zenghui Chang (Author), Junshuo Zhang (Author), Yufeng Chen (Author), Jiale Liu (Author), Guohao Sun (Author), Yiyuan Wang (Author), Yuanyuan Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Our previous studies substantiated that the biological activity of Schisandra chinensis lignans during the treatment of Alzheimer's disease (AD) was mediated by neurotransmitter levels, and 15 of its active components were identified. However, the pharmacokinetic and pharmacodynamic...