Synthesis and Evaluation of Small Molecule Drug Conjugates Harnessing Thioester-Linked Maytansinoids

• Main Authors: Chen-Fu Lo (Author), Tai-Yu Chiu (Author), Yu-Tzu Liu (Author), Li-Rung Huang (Author), Teng-Kuang Yeh (Author), Kuan-Hsun Huang (Author), Kuan-Liang Liu (Author), Chia-Yu Hsu (Author), Ming-Yu Fang (Author), Yu-Chen Huang (Author), Tsu-An Hsu (Author), Chiung-Tong Chen (Author), Lun Kelvin Tsou (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ligand-targeting drug conjugates are a class of clinically validated biopharmaceutical drugs constructed by conjugating cytotoxic drugs with specific disease antigen targeting ligands through appropriate linkers. The integrated linker-drug motif embedded within such a system can prevent the prematur...