GOLGA8 increases bulk antisense oligonucleotide uptake and activity in mammalian cells

Antisense oligonucleotides (ASOs) are short synthetic nucleic acids that recognize and bind to complementary RNA to modulate gene expression. It is well established that single-stranded, phosphorothioate-modified ASOs enter cells independent of carrier molecules, primarily via endocytic pathways, bu...

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Main Authors: Moira A. McMahon (Author), Meghdad Rahdar (Author), Swagatam Mukhopadhyay (Author), Huynh-Hoa Bui (Author), Christopher Hart (Author), Sagar Damle (Author), Margo Courtney (Author), Michael W. Baughn (Author), Don W. Cleveland (Author), C. Frank Bennett (Author)
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Publicado em: Elsevier, 2023-06-01T00:00:00Z.
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