GOLGA8 increases bulk antisense oligonucleotide uptake and activity in mammalian cells

• Main Authors: Moira A. McMahon (Author), Meghdad Rahdar (Author), Swagatam Mukhopadhyay (Author), Huynh-Hoa Bui (Author), Christopher Hart (Author), Sagar Damle (Author), Margo Courtney (Author), Michael W. Baughn (Author), Don W. Cleveland (Author), C. Frank Bennett (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antisense oligonucleotides (ASOs) are short synthetic nucleic acids that recognize and bind to complementary RNA to modulate gene expression. It is well established that single-stranded, phosphorothioate-modified ASOs enter cells independent of carrier molecules, primarily via endocytic pathways, bu...