GOLGA8 increases bulk antisense oligonucleotide uptake and activity in mammalian cells

• मुख्य लेखकों: Moira A. McMahon (लेखक), Meghdad Rahdar (लेखक), Swagatam Mukhopadhyay (लेखक), Huynh-Hoa Bui (लेखक), Christopher Hart (लेखक), Sagar Damle (लेखक), Margo Courtney (लेखक), Michael W. Baughn (लेखक), Don W. Cleveland (लेखक), C. Frank Bennett (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Antisense oligonucleotides (ASOs) are short synthetic nucleic acids that recognize and bind to complementary RNA to modulate gene expression. It is well established that single-stranded, phosphorothioate-modified ASOs enter cells independent of carrier molecules, primarily via endocytic pathways, bu...