Alteration in Metabolism and Toxicity of Acetaminophen Upon Repeated Administration in Rats

• मुख्य लेखकों: Sun J. Kim (लेखक), Min Y. Lee (लेखक), Do Y. Kwon (लेखक), Sung Y. Kim (लेखक), Young C. Kim (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2009-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Our previous studies showed that administration of a subtoxic dose of acetaminophen (APAP) to female rats increased generation of carbon monoxide from dichloromethane, a metabolic reaction catalyzed mainly by cytochrome P450 (CYP) 2E1. In this study we examined the changes in metabolism and toxicity...