Optimizing pH-sensitive and time-dependent polymer formula of colonic pH-responsive pellets to achieve precise drug release

• Main Authors: Lijun Song (Author), Liping Liang (Author), Xiaoying Shi (Author), Honglang Chen (Author), Shumin Zhao (Author), Wenfeng Chen (Author), Ruoxia Zhou (Author), Wenchang Zhao (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Time-sensitive and pH-dependent polymers are generally employed to prepare colon-site delivery system, and their coating thickness and order are very important in controlling the drug release. The traditional colon-site delivery systems consist of time-dependent polymers as inner layer and pH-sensit...