No dose adjustment of metformin or substrates of organic cation transporters (OCT)1 and OCT2 and multidrug and toxin extrusion protein (MATE)1/2K with fostemsavir coadministration based on modeling approaches

• Hlavní autoři: Dung Nguyen (Autor), Xiusheng Miao (Autor), Kunal Taskar (Autor), Mindy Magee (Autor), Pete Gorycki (Autor), Katy Moore (Autor), Guoying Tai (Autor)
• Médium: Kniha
• Vydáno: Wiley, 2024-08-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Abstract Fostemsavir is an approved gp120‐directed attachment inhibitor and prodrug for the treatment of human immunodeficiency virus type 1 infection in combination with other antiretrovirals (ARVs) in heavily treatment‐experienced adults with multi‐drug resistance, intolerance, or safety concerns...