Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

• Главные авторы: Timothy J. Bauler (Автор), Nobuhiro Kamiya (Автор), Philip E. Lapinski (Автор), Eric Langewisch (Автор), Yuji Mishina (Автор), John E. Wilkinson (Автор), Gen-Sheng Feng (Автор), Philip D. King (Автор)
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• Опубликовано: The Company of Biologists, 2011-03-01T00:00:00Z.
• Предметы: article
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SUMMARY SHP-2 (encoded by PTPN11) is a ubiquitously expressed protein tyrosine phosphatase required for signal transduction by multiple different cell surface receptors. Humans with germline SHP-2 mutations develop Noonan syndrome or LEOPARD syndrome, which are characterized by cardiovascular, neuro...