Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

SUMMARY SHP-2 (encoded by PTPN11) is a ubiquitously expressed protein tyrosine phosphatase required for signal transduction by multiple different cell surface receptors. Humans with germline SHP-2 mutations develop Noonan syndrome or LEOPARD syndrome, which are characterized by cardiovascular, neuro...

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Main Authors: Timothy J. Bauler (Author), Nobuhiro Kamiya (Author), Philip E. Lapinski (Author), Eric Langewisch (Author), Yuji Mishina (Author), John E. Wilkinson (Author), Gen-Sheng Feng (Author), Philip D. King (Author)
Format: Book
Published: The Company of Biologists, 2011-03-01T00:00:00Z.
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