Association of clock-like mutational signature with immune checkpoint inhibitor outcome in patients with melanoma and NSCLC

• Main Authors: Wei Chong (Author), Zhe Wang (Author), Liang Shang (Author), Shengtao Jia (Author), Jin Liu (Author), Zhen Fang (Author), Fengying Du (Author), Hao Wu (Author), Yang Liu (Author), Yang Chen (Author), Hao Chen (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immune checkpoint inhibitor (ICI) therapy has achieved remarkable clinical benefit in melanoma and non-small cell lung cancer (NSCLC). Tumor mutational signatures are the fingerprints of endogenous and exogenous factors that have acted throughout tumorigenesis and heterogeneity; however, their assoc...