Optimization of the cyclotide framework to improve cell penetration properties

• Main Authors: Yen-Hua eHuang (Author), Stephanie eChaousis (Author), Olivier eCheneval (Author), David J. Craik (Author), Sonia eTroeira Henriques (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cell penetrating peptides have been regarded as promising vectors to deliver hydrophilic molecules inside cells. Although they are great tools for research and have high potential as drug delivery systems, their application as drugs is impaired by their low stability in serum. Cyclotides, cyclic dis...